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Journal article

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.

Abstract:

Biallelic CEBPA mutations and FMS-like tyrosine kinase receptor 3 (FLT3) length mutations are frequently identified in human acute myeloid leukemia (AML) with normal cytogenetics. However, the molecular and cellular mechanisms of oncogene cooperation remain unclear because of a lack of disease models. We have generated an AML mouse model using knockin mouse strains to study cooperation of an internal tandem duplication (ITD) mutation in the Flt3 gene with commonly observed CCAAT/enhancer bind...

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Publication status:
Published

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Publisher copy:
10.1038/leu.2012.37

Authors


Reckzeh, K More by this author
Bereshchenko, O More by this author
Kharazi, S More by this author
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Journal:
Leukemia
Volume:
26
Issue:
7
Pages:
1527-1536
Publication date:
2012-07-05
DOI:
EISSN:
1476-5551
ISSN:
0006-4971
URN:
uuid:b64b4758-20c2-449f-a7d2-4f5d13fb98db
Source identifiers:
313937
Local pid:
pubs:313937

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