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Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS.

Abstract:

Many disease-related processes occur via protein complexes that are considered undruggable with small molecules. An example is RAS, which is frequently mutated in cancer and contributes to initiation and maintenance of the disease by constitutive signal transduction through protein interaction with effector proteins, like PI3K, RAF and RALGDS. Such protein interactions are therefore significant targets for therapy. We describe a single immunoglobulin variable region domain that specifically b...

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Publisher copy:
10.1038/sj.emboj.7601744

Authors


Williams, RL More by this author
Rabbitts, TH More by this author
Journal:
The EMBO journal
Volume:
26
Issue:
13
Pages:
3250-3259
Publication date:
2007-07-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:b639f4be-6dbf-41a2-8159-8b1a481332b3
Source identifiers:
324265
Local pid:
pubs:324265

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