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Apolipoprotein E genotype, gender and age modulate connectivity of the hippocampus in healthy adults.

Abstract:

Important risk factors for Alzheimer's disease (AD) are ageing and the Apolipoprotein E (APOE) ε4 allele, with female APOE ε4 carriers having the greatest risk. In this study we investigated effects of AD risk factors on connectivity of the hippocampus, a structure that shows early AD related pathology. Resting-state functional magnetic resonance imaging and diffusion tensor imaging data from 86 cognitively healthy subjects aged 30 to 78years were analysed. Female APOE ε4 carriers showed over...

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Publication status:
Published

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Authors


Filippini, N More by this author
Trachtenberg, AJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
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Publisher:
Academic Press Inc.
Journal:
NeuroImage
Volume:
98
Pages:
23-30
Publication date:
2014-09-05
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
URN:
uuid:b639c04d-9c3e-4af7-88b4-17a400348f37
Source identifiers:
464913
Local pid:
pubs:464913

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