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Directed microbial biosynthesis of deuterated biosurfactants and potential future application to other bioactive molecules.

Abstract:

Deuterated rhamnolipids were produced using strain AD7 of Pseudomonas aeruginosa, which was progressively adapted to increasing levels of deuterium in D(2)O and carbon substrates. Fourteen different deuterated rhamnolipid structures, including structural isomers, were produced which is similar to normal protonated structures. There were two main products monorhamnolipid Rha-C(10)-C(10) and dirhamnolipid Rha(2)-C(10)-C(10). The levels of deuteration varied from 16% with 25% D(2)O + h-glycerol ...

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Publication status:
Published

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Publisher copy:
10.1007/s00253-010-2592-5

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Journal:
Applied microbiology and biotechnology
Volume:
87
Issue:
4
Pages:
1347-1354
Publication date:
2010-07-05
DOI:
EISSN:
1432-0614
ISSN:
0175-7598
URN:
uuid:b639637b-d31e-47e5-8eeb-eda07a698291
Source identifiers:
65332
Local pid:
pubs:65332

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