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Identification of a clonally restricted 90 kD heterodimer on two human cloned natural killer cell lines. Its role in cytotoxic effector function.

Abstract:

The present studies were carried out to identify surface molecules involved in the cytotoxic effector function of a human natural killer (NK) clone termed JT9. This clone represents a mature T lymphocyte (T3+T8+T11+) mediating NK-like activity. Using JT9 for immunization, one monoclonal antibody termed anti-NKTa was selected that blocked the cytotoxicity of the clone towards K562 cells. Reactivity of anti-NKTa antibody was assessed using a large panel of lymphoid and nonlymphoid cells includi...

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Publication status:
Published

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Publisher copy:
10.1084/jem.158.5.1547

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Journal:
Journal of experimental medicine
Volume:
158
Issue:
5
Pages:
1547-1560
Publication date:
1983-11-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
24720
Language:
English
Keywords:
Pubs id:
pubs:24720
UUID:
uuid:b637dc61-22bd-479a-a436-dff332ce0fd6
Local pid:
pubs:24720
Deposit date:
2012-12-19

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