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Characterizing SARS-CoV-2 viral clearance kinetics to improve the design of antiviral pharmacometric studies

Abstract:

A consensus methodology for the pharmacometric assessment of candidate SARS-CoV-2 antiviral drugs would be useful for comparing trial results and improving trial design. The time to viral clearance, assessed by serial qPCR of nasopharyngeal swab samples, has been the most widely reported measure of virological response in clinical trials, but it has not been compared formally with other metrics, notably model-based estimates of the rate of viral clearance. We analyzed prospectively gathered v...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.00192-22

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0001-5524-0325
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-2309-1171
More by this author
Role:
Author
ORCID:
0000-0001-5646-1314
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-1897-1978
Publisher:
American Society for Microbiology
Journal:
Antimicrobial Agents and Chemotherapy More from this journal
Volume:
66
Issue:
7
Article number:
e0019222
Place of publication:
United States
Publication date:
2022-06-23
Acceptance date:
2022-06-06
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pmid:
35736134
Language:
English
Keywords:
Pubs id:
1265620
Local pid:
pubs:1265620
Deposit date:
2023-02-21

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