Journal article icon

Journal article

Differential effects of Th1 versus Th2 cytokines in combination with hypoxia on HIFs and angiogenesis in RA.

Abstract:

INTRODUCTION: Hypoxia and T-helper cell 1 (Th1) cytokine-driven inflammation are key features of rheumatoid arthritis (RA) and contribute to disease pathogenesis by promoting angiogenesis. The objective of our study was to characterise the angiogenic gene signature of RA fibroblast-like synoviocytes (FLS) in response to hypoxia, as well as Th1 and T-helper cell 2 (Th2) cytokines, and in particular to dissect out effects of combined hypoxia and cytokines on hypoxia inducible transcription fact...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1186/ar3934

Authors


More by this author
Institution:
University of Oxford
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Arthritis Research UK More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Arthritis Research and Therapy Journal website
Volume:
14
Issue:
4
Pages:
Article: R180
Publication date:
2012
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
URN:
uuid:b62d421f-3e63-42f0-a708-357b0e207cab
Source identifiers:
345699
Local pid:
pubs:345699
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP