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Differential effects of Th1 versus Th2 cytokines in combination with hypoxia on HIFs and angiogenesis in RA.

Abstract:

INTRODUCTION: Hypoxia and T-helper cell 1 (Th1) cytokine-driven inflammation are key features of rheumatoid arthritis (RA) and contribute to disease pathogenesis by promoting angiogenesis. The objective of our study was to characterise the angiogenic gene signature of RA fibroblast-like synoviocytes (FLS) in response to hypoxia, as well as Th1 and T-helper cell 2 (Th2) cytokines, and in particular to dissect out effects of combined hypoxia and cytokines on hypoxia inducible transcription fact...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/ar3934

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Institution:
University of Oxford
Role:
Author
Arthritis Research UK More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Arthritis Research and Therapy Journal website
Volume:
14
Issue:
4
Article number:
R180
Publication date:
2012-01-01
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
Source identifiers:
345699
Language:
English
UUID:
uuid:b62d421f-3e63-42f0-a708-357b0e207cab
Local pid:
pubs:345699
Deposit date:
2012-12-19

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