Journal article icon

Journal article

Functionalised pyrrolidinones derived from (S)-pyroglutamic acid

Abstract:
The generation of the lactam enolate derived from bicyclic lactams 2a-c, prepared from (S)-pyroglutamic acid 1a, and subsequent reaction with a range of electrophiles, is reported. Exo-diastereoselectivity is generally favoured. The deprotection of some of these adducts to give functionalised hydroxymethylpyrrolidinones is readily achieved by simple hemiaminal ether cleavage under acidic conditions.
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
TETRAHEDRON More from this journal
Volume:
52
Issue:
10
Pages:
3719-3740
Publication date:
1996-03-04
DOI:
ISSN:
0040-4020
Language:
English
Pubs id:
pubs:45071
UUID:
uuid:b6272198-0057-4a94-8f01-642dd6fc7432
Local pid:
pubs:45071
Source identifiers:
45071
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP