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Thesis

Modulation of oscillatory activity in the cortico-subthalamic pathway by electrical stimulation in rodents and humans

Abstract:

Parkinson’s disease (PD) is a debilitating motor disorder characterized by degeneration of dopaminergic cells in the Basal Ganglia (BG). This loss of dopaminergic neurons gives rise to abnormal synchronization of neuronal activity in the beta frequency range (around 20 Hz) across the cortico-basal ganglia network in parkinsonian humans and animals. Interestingly, in tremor patients the phase of ongoing peripheral oscillation can be exploited with electrical ‘phase interference’, whereby co...

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Eszter Kormann
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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