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The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells

Abstract:

The EWS-ERG fusion protein is found in human sarcomas with the chromosomal translocation t(21;22)(q22;q12), where the translocation is considered to be an initiating event in sarcoma formation within uncommitted mesenchymal cells, probably long-lived progenitors capable of self renewal. The fusion protein may not therefore have an oncogenic capability beyond these progenitors. To assess whether EWS-ERG can be a tumour initiator in cells other than mesenchymal cells, we have analysed Ews-ERG f...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pbio.0030242

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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Biology Journal website
Volume:
3
Issue:
8
Pages:
e242
Publication date:
2005-06-28
Acceptance date:
2005-05-09
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
Source identifiers:
324271

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