Journal article
The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells
- Abstract:
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The EWS-ERG fusion protein is found in human sarcomas with the chromosomal translocation t(21;22)(q22;q12), where the translocation is considered to be an initiating event in sarcoma formation within uncommitted mesenchymal cells, probably long-lived progenitors capable of self renewal. The fusion protein may not therefore have an oncogenic capability beyond these progenitors. To assess whether EWS-ERG can be a tumour initiator in cells other than mesenchymal cells, we have analysed Ews-ERG f...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 292.4KB)
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- Publisher copy:
- 10.1371/journal.pbio.0030242
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Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Biology Journal website
- Volume:
- 3
- Issue:
- 8
- Pages:
- e242
- Publication date:
- 2005-06-28
- Acceptance date:
- 2005-05-09
- DOI:
- EISSN:
-
1545-7885
- ISSN:
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1544-9173
- Source identifiers:
-
324271
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:b62223ff-b6e2-4a6d-a28f-6c8e1ccc48ad
- Local pid:
- pubs:324271
- Deposit date:
- 2013-11-16
Terms of use
- Copyright holder:
- Codrington et al
- Copyright date:
- 2005
- Notes:
- © 2005 Codrington et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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