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Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients

Abstract:

We previously identified autoantibodies to the endocytic-associated protein Huntingtin-interacting protein 1-related (HIP1R) in diffuse large B-cell lymphoma (DLBCL) patients. HIP1R regulates internalization of cell surface receptors via endocytosis, a process relevant to many therapeutic strategies including CD20 targeting with rituximab. In this study, we characterized HIP1R expression patterns, investigated a mechanism of transcriptional regulation and its clinical relevance in DLBCL patie...

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Publisher copy:
10.1038/leu.2013.224

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Journal:
Leukemia More from this journal
Volume:
28
Issue:
2
Pages:
362-372
Publication date:
2014-02-01
DOI:
EISSN:
1476-5551
ISSN:
0887-6924
Language:
English
Keywords:
Pubs id:
pubs:449614
UUID:
uuid:b61f0e9c-f27b-4723-94b6-20e7b8af2ca1
Local pid:
pubs:449614
Source identifiers:
449614
Deposit date:
2014-09-14

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