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Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds.

Abstract:

The age of onset of Huntington's disease (HD) is inversely correlated with the CAG length in the HD gene. The CAG repeat length accounts for 70% of the variability in HD age of onset. However, 90% of individuals worldwide with expanded alleles possess between 40 and 50 CAG repeat lengths in their HD gene. For these people, the size of their repeat only determines 44% of the variability in their age of onset. Once the effect of the CAG repeat has been accounted for, the residual variance in ag...

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Publication status:
Published

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Publisher copy:
10.1002/gepi.20317

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Journal:
Genetic epidemiology More from this journal
Volume:
32
Issue:
5
Pages:
445-453
Publication date:
2008-07-01
DOI:
EISSN:
1098-2272
ISSN:
0741-0395
Language:
English
Keywords:
Pubs id:
pubs:114750
UUID:
uuid:b61d8e6b-f43d-4e03-9274-86696aba5a8d
Local pid:
pubs:114750
Source identifiers:
114750
Deposit date:
2013-11-16

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