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Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions.

Abstract:

Genetic diversity of viral isolates in human immunodeficiency virus (HIV)-infected individuals varies substantially. However, it remains unclear whether HIV-related disease progresses more rapidly in patients harboring virus swarms with low or high diversity and, in the same context, whether high or low diversity is required to induce potent humoral and cellular immune responses. To explore whether viral diversity predicts virologic control, we studied HIV-infected patients who received antir...

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Publication status:
Published

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Journal:
Journal of virology
Volume:
79
Issue:
14
Pages:
9026-9037
Publication date:
2005-07-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Source identifiers:
24003
Language:
English
Keywords:
Pubs id:
pubs:24003
UUID:
uuid:b619817a-a37c-48ff-b1e5-590ff49a4c73
Local pid:
pubs:24003
Deposit date:
2012-12-19

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