Journal article icon

Journal article

A requirement for Zic2 in the regulation of nodal expression underlies the establishment of left-sided identity

Abstract:

ZIC2 mutation is known to cause holoprosencephaly (HPE). A subset of ZIC2 HPE probands harbour cardiovascular and visceral anomalies suggestive of laterality defects. 3D-imaging of novel mouse Zic2 mutants uncovers, in addition to HPE, laterality defects in lungs, heart, vasculature and viscera. A strong bias towards right isomerism indicates a failure to establish left identity in the lateral plate mesoderm (LPM), a phenotype that cannot be explained simply by the defective ciliogenesis prev...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41598-018-28714-1

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
ORCID:
0000-0002-7007-3649
Expand authors...
More from this funder
Funding agency for:
Bhattacharya, S
Grant:
090532/Z/09/Z
More from this funder
Funding agency for:
Bhattacharya, S
Grant:
090532/Z/09/Z
More from this funder
Funding agency for:
Schneider, J
Grant:
FS/11/50/29038
More from this funder
Funding agency for:
Dykes, I
Grant:
RE/13/1/30181
Publisher:
Springer Nature Publisher's website
Journal:
Scientific reports Journal website
Volume:
8
Article number:
10439
Publication date:
2018-07-11
Acceptance date:
2018-06-25
DOI:
EISSN:
2045-2322
Pmid:
29992973
Language:
English
Pubs id:
pubs:868960
UUID:
uuid:b615d629-ab40-4809-9a25-22095b00d71d
Local pid:
pubs:868960
Deposit date:
2018-11-15

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP