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Journal article

Dry-coated live viral vector vaccines delivered by nanopatch microprojections retain long-term thermostability and induce transgene-specific T cell responses in mice

Abstract:

The disadvantages of needle-based immunisation motivate the development of simple, low cost, needle-free alternatives. Vaccine delivery to cutaneous environments rich in specialised antigen-presenting cells using microprojection patches has practical and immunological advantages over conventional needle delivery. Additionally, stable coating of vaccine onto microprojections removes logistical obstacles presented by the strict requirement for cold-chain storage and distribution of liquid vacci...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0067888

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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
8
Issue:
7
Pages:
e67888
Publication date:
2013-07-09
Acceptance date:
2013-05-23
DOI:
EISSN:
1932-6203
Source identifiers:
414692
Language:
English
Keywords:
Pubs id:
pubs:414692
UUID:
uuid:b61485f1-4067-450a-9a47-947c9ffb9521
Local pid:
pubs:414692
Deposit date:
2013-11-17

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