Journal article
Dry-coated live viral vector vaccines delivered by nanopatch microprojections retain long-term thermostability and induce transgene-specific T cell responses in mice
- Abstract:
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The disadvantages of needle-based immunisation motivate the development of simple, low cost, needle-free alternatives. Vaccine delivery to cutaneous environments rich in specialised antigen-presenting cells using microprojection patches has practical and immunological advantages over conventional needle delivery. Additionally, stable coating of vaccine onto microprojections removes logistical obstacles presented by the strict requirement for cold-chain storage and distribution of liquid vacci...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.2MB)
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- Publisher copy:
- 10.1371/journal.pone.0067888
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Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 8
- Issue:
- 7
- Pages:
- e67888
- Publication date:
- 2013-07-09
- Acceptance date:
- 2013-05-23
- DOI:
- EISSN:
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1932-6203
- Source identifiers:
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414692
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:414692
- UUID:
-
uuid:b61485f1-4067-450a-9a47-947c9ffb9521
- Local pid:
- pubs:414692
- Deposit date:
- 2013-11-17
Terms of use
- Copyright holder:
- Pearson et al
- Copyright date:
- 2013
- Notes:
- © 2013 Pearson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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