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Biochemical investigation of human tumours in vivo with phosphorus-31 magnetic resonance spectroscopy.

Abstract:

The bioenergetic state of 15 human tumours was examined with phosphorus-31 magnetic resonance spectroscopy. A striking diversity in metabolic patterns was observed, and significant differences from normal tissue were seen in all cases. A common feature was an elevation of intracellular pH, which may be related to an increase in Na+/H+ exchange during cell activation. It is unlikely that the patterns observed directly correlate with malignancy, but characterisation of the energetic state of a ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Lancet
Volume:
2
Issue:
8497
Pages:
8-11
Publication date:
1986-07-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:b608b17c-cd4f-414c-90e7-ab7d41f1bbfb
Source identifiers:
248114
Local pid:
pubs:248114

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