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Accumulation of 2-deoxy-D-glucose-6-phosphate as a measure of glucose uptake in the isolated perfused heart: a 31P NMR study.

Abstract:

The accumulation of 2-deoxy-D-glucose-6-phosphate (2DG6P), detected using 31P NMR spectroscopy, has been used as a measure of the rate of glucose uptake, yet the accuracy of this measurement has not been verified. In this study, isolated rat hearts were perfused with different substrates or isoproterenol for 30 min before measurement of either 2DG6P accumulation or [2-3H]glucose uptake, without and with insulin. Basal contractile function and metabolite concentrations were the same for all he...

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Publication status:
Published

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Publisher copy:
10.1016/j.ymben.2003.10.002

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Metabolic engineering More from this journal
Volume:
6
Issue:
1
Pages:
36-43
Publication date:
2004-01-01
DOI:
EISSN:
1096-7184
ISSN:
1096-7176
Language:
English
Keywords:
Pubs id:
pubs:106402
UUID:
uuid:b6062bef-28cb-41b6-a766-a6b0f6733c0a
Local pid:
pubs:106402
Source identifiers:
106402
Deposit date:
2013-11-17

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