Thesis
Effects of altering CpG dinucleotide composition in small DNA viruses
- Abstract:
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CpG dinucleotides are underrepresented in mammalian genomes and in many viruses infecting them. Previous studies have shown that increasing CpG frequencies in various RNA viruses and retroviruses reduces replicative fitness but the effects of this compositional modification are unknown in DNA viruses. To investigate this, the effects of increasing CpG frequencies were determined in the parvovirus minute virus of mice (MVM) at various stages of the viral life cycle and a system was set up f...
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Authors
Contributors
+ Simmonds, P
Role:
Supervisor
+ Klenerman, P
Role:
Supervisor
ORCID:
0000-0003-4307-9161
+ Fodor, E
Role:
Examiner
ORCID:
0000-0003-3249-196X
+ Randall, R
Role:
Examiner
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2021-04-07
Related Items
Terms of use
- Copyright holder:
- Loew, L
- Copyright date:
- 2020
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