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Thesis

Effects of altering CpG dinucleotide composition in small DNA viruses

Abstract:

CpG dinucleotides are underrepresented in mammalian genomes and in many viruses infecting them. Previous studies have shown that increasing CpG frequencies in various RNA viruses and retroviruses reduces replicative fitness but the effects of this compositional modification are unknown in DNA viruses. To investigate this, the effects of increasing CpG frequencies were determined in the parvovirus minute virus of mice (MVM) at various stages of the viral life cycle and a system was set up f...

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Division:
MSD
Role:
Author

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Role:
Supervisor
Role:
Supervisor
ORCID:
0000-0003-4307-9161
Role:
Examiner
ORCID:
0000-0003-3249-196X
Role:
Examiner
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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