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Combining virotherapy and angiotherapy for the treatment of breast cancer

Abstract:

A breast cancer-selective oncolytic adenovirus was engineered to express antagonists of vascular endothelial growth factor (VEGF) and Notch signaling to combine direct anticancer activity with disruption of tumor-associated angiogenesis. Replication of the parental virus, AdEHE2F, is stimulated by estrogen receptor (ER), E2F1 and hypoxia, and it mediates selective lysis of breast cancer cells in vitro and in vivo. Here, we encoded soluble Flt-1 (sFlt1) and soluble Dll4 (sDll4) under control o...

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Publisher copy:
10.1038/cgt.2013.41

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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Role:
Author
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Journal:
Cancer Gene Therapy
Volume:
20
Issue:
8
Pages:
461-468
Publication date:
2013-08-05
DOI:
EISSN:
1476-5500
ISSN:
0929-1903
URN:
uuid:b6012225-da6d-48d1-bd0a-7de318530bc0
Source identifiers:
425520
Local pid:
pubs:425520

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