Journal article icon

Journal article

Refined genetic mapping of the darier locus to a <1-cM region of chromosome 12q24.1, and construction of a complete, high-resolution P1 artificial chromosome/bacterial artificial chromosome contig of the critical region.

Abstract:

Darier disease (DD) (MIM 124200) is an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and by abnormal keratinization. We present linkage analysis showing, in four families, key recombination events that refine the location of the DD locus on chromosome 12q23-24.1 to a region of <1 cM. We have constructed a YAC/P1 artificial chromosome (PAC)/bacterial artificial chromosome (BAC)-based physical map that encompasses this refined DD region. The map c...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1086/301794

Authors


Journal:
American journal of human genetics More from this journal
Volume:
62
Issue:
4
Pages:
890-903
Publication date:
1998-04-01
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Language:
English
Keywords:
Pubs id:
pubs:36165
UUID:
uuid:b5fe358d-6e5e-45fc-b507-8dfa9731cdfa
Local pid:
pubs:36165
Source identifiers:
36165
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP