Journal article
Instrumental variables and interactions in the causal analysis of a complex clinical trial.
- Abstract:
-
We consider the application of instrumental variable techniques in a longitudinal clinical trial in paediatric HIV/AIDS, with a substantial degree of non-compliance to randomized treatment (Nelfinavir versus placebo) and with left censoring of the outcome variable (HIV RNA concentration). We consider in detail the assumptions and implications behind the inclusion and exclusion of interactions between randomized arm and baseline covariates in modelling actual treatment received, and between tr...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/sim.2644
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Authors
Bibliographic Details
- Journal:
- Statistics in medicine
- Volume:
- 26
- Issue:
- 7
- Pages:
- 1473-1496
- Publication date:
- 2007-03-01
- DOI:
- EISSN:
-
1097-0258
- ISSN:
-
0277-6715
- Source identifiers:
-
422983
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:422983
- UUID:
-
uuid:b5f4fa3c-7a71-40eb-88a2-66812e93e0f1
- Local pid:
- pubs:422983
- Deposit date:
- 2014-02-08
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- Copyright date:
- 2007
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