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Journal article

Loss of two-pore channel 2 (tpc2) expression increases the metastatic traits of melanoma cells by a mechanism involving the hippo signalling pathway and store-operated calcium entry

Abstract:

Melanoma is one of the most aggressive and treatment-resistant human cancers. The two-pore channel 2 (TPC2) is located on late endosomes, lysosomes and melanosomes. Here, we characterized how TPC2 knockout (KO) affected human melanoma cells derived from a metastatic site. TPC2 KO increased these cells’ ability to invade the extracelullar matrix and was associated with the increased expression of mesenchymal markers ZEB-1, Vimentin and N-Cadherin, and the enhanced secretion of MMP9. TPC2 KO al...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/cancers12092391

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
ORCID:
0000-0002-3441-4397
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Role:
Author
ORCID:
0000-0003-3730-1125
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Role:
Author
ORCID:
0000-0002-8276-0438
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Publisher:
MDPI Publisher's website
Journal:
Cancers Journal website
Volume:
12
Issue:
9
Article number:
2391
Publication date:
2020-08-24
Acceptance date:
2020-08-18
DOI:
EISSN:
2072-6694
Pmid:
32846966
Language:
English
Keywords:
Pubs id:
1131321
Local pid:
pubs:1131321
Deposit date:
2021-08-24

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