- Abstract:
-
BACKGROUND: Male factor and idiopathic infertility contribute significantly to global infertility, with abnormal testicular gene expression considered to be a major cause. Certain types of male infertility are caused by failure of the sperm to activate the oocyte, a process normally regulated by calcium oscillations, thought to be induced by a sperm-specific phospholipase C, PLCzeta (PLCζ). Previously, we identified a point mutation in an infertile male resulting in the substitution of histid...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/humrep/der384
-
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- Journal:
- Human reproduction (Oxford, England)
- Volume:
- 27
- Issue:
- 1
- Pages:
- 222-231
- Publication date:
- 2012-01-05
- DOI:
- EISSN:
-
1460-2350
- ISSN:
-
0268-1161
- URN:
-
uuid:b5ecb101-875f-4990-ae72-8b35c855ae33
- Source identifiers:
-
206002
- Local pid:
- pubs:206002
- Copyright date:
- 2012
Journal article
A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility.
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