Journal article icon

Journal article

A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility.

Abstract:

BACKGROUND: Male factor and idiopathic infertility contribute significantly to global infertility, with abnormal testicular gene expression considered to be a major cause. Certain types of male infertility are caused by failure of the sperm to activate the oocyte, a process normally regulated by calcium oscillations, thought to be induced by a sperm-specific phospholipase C, PLCzeta (PLCζ). Previously, we identified a point mutation in an infertile male resulting in the substitution of histid...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/humrep/der384

Authors


Konstantinidis, M More by this author
Expand authors...
Journal:
Human reproduction (Oxford, England)
Volume:
27
Issue:
1
Pages:
222-231
Publication date:
2012-01-05
DOI:
EISSN:
1460-2350
ISSN:
0268-1161
URN:
uuid:b5ecb101-875f-4990-ae72-8b35c855ae33
Source identifiers:
206002
Local pid:
pubs:206002

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP