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Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia.

Abstract:

The acquisition of uniparental disomy (aUPD) in acute myeloid leukemia (AML) results in homozygosity for known gene mutations. Uncovering novel regions of aUPD has the potential to identify previously unknown mutational targets. We therefore aimed to develop a map of the regions of aUPD in AML. Here, we have analyzed a large set of diagnostic AML samples (n = 454) from young adults (age: 15-55 years) using genotype arrays. Acquired UPD was found in 17% of the samples with a nonrandom distribu...

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Publisher copy:
10.1002/gcc.20573

Authors


Journal:
Genes, chromosomes and cancer More from this journal
Volume:
47
Issue:
9
Pages:
729-739
Publication date:
2008-09-01
DOI:
EISSN:
1098-2264
ISSN:
1045-2257
Language:
English
Keywords:
Pubs id:
pubs:291020
UUID:
uuid:b5e07785-815f-4277-866c-fa046282692e
Local pid:
pubs:291020
Source identifiers:
291020
Deposit date:
2012-12-19

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