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Journal article

Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.

Abstract:

A defect in indoleamine 2,3-dioxygenase 1 (IDO1), which is responsible for immunoregulatory tryptophan catabolism, impairs development of immune tolerance to autoantigens in NOD mice, a model for human autoimmune type 1 diabetes (T1D). Whether IDO1 function is also defective in T1D is still unknown. We investigated IDO1 function in sera and peripheral blood mononuclear cells (PBMCs) from children with T1D and matched controls. These children were further included in a discovery study to ident...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci.insight.96244

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Publisher:
American Society for Clinical Investigation (ASCI) Publisher's website
Journal:
JCI insight Journal website
Volume:
3
Issue:
6
Pages:
Article: e96244
Publication date:
2018-03-22
Acceptance date:
2018-02-13
DOI:
EISSN:
2379-3708
Pubs id:
pubs:831860
URN:
uri:b5de47f0-51f3-42e6-ab55-40b6befebea3
UUID:
uuid:b5de47f0-51f3-42e6-ab55-40b6befebea3
Local pid:
pubs:831860

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