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Artemether-lumefantrine coadministration with antiretrovirals; population pharmacokinetics and dosing implications.

Abstract:

AIM: Drug-drug interactions between antimalarial and antiretroviral drugs may influence antimalarial treatment outcomes. The aim of this study was to investigate the potential drug-drug interactions between the anti-malarial drugs; lumefantrine, artemether and their respective metabolites desbutyl-lumefantrine and dihydroartemisinin, and the HIV-drugs efavirenz, nevirapine and lopinavir/ritonavir. METHOD: Data from two clinical studies, investigating the influence of the HIV-drugs efavirenz, ...

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Publisher copy:
10.1111/bcp.12529

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Journal:
British journal of clinical pharmacology
Pages:
n/a-n/a
Publication date:
2014-10-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:b5de0ae6-537e-4437-94fd-888642eeaaea
Source identifiers:
486689
Local pid:
pubs:486689

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