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Modulation of SF1 neuron activity coordinately regulates both feeding behavior and associated emotional states

Abstract:

Feeding requires the integration of homeostatic drives with emotional states relevant to food procurement in potentially hostile environments. The ventromedial hypothalamus (VMH) regulates feeding and anxiety, but how these are controlled in a concerted manner remains unclear. Using pharmacogenetic, optogenetic, and calcium imaging approaches with a battery of behavioral assays, we demonstrate that VMH steroidogenic factor 1 (SF1) neurons constitute a nutritionally sensitive switch, modulatin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2017.11.089

Authors


Viskaitis, P More by this author
Irvine, EE More by this author
Choudhury, AI More by this author
Alvarez-Curto, E More by this author
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Grant:
to D.J.W. (MC-A654-5QB40) and M.A.U. (MC-A654-5QB70)
Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
21
Issue:
12
Pages:
3559-3572
Publication date:
2017-12-19
Acceptance date:
2017-11-27
DOI:
ISSN:
2211-1247
Pubs id:
pubs:813207
URN:
uri:b5dc86f7-fd97-4e4c-8016-2b8c67dde260
UUID:
uuid:b5dc86f7-fd97-4e4c-8016-2b8c67dde260
Local pid:
pubs:813207

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