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Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.

Abstract:

Treatment with monoclonal antibodies (mAbs) specific for CD25 (anti-CD25 mAb) has been shown to suppress growth of a variety of different tumours in mice. These studies did not however determine whether or not anti-CD25 mAbs facilitate tumour rejection by depletion of regulatory T cells or by binding to tumour-specific effector cells. Using a murine model of melanoma we have found that treatment of mice with anti-CD25 mAb facilitates long-term CD4+ T cell-mediated tumour immunity through depl...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Journal:
Cancer immunity
Volume:
2
Pages:
1
Publication date:
2002-02-01
EISSN:
1424-9634
ISSN:
1424-9634
Source identifiers:
26100

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