Journal article
Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.
- Abstract:
-
Treatment with monoclonal antibodies (mAbs) specific for CD25 (anti-CD25 mAb) has been shown to suppress growth of a variety of different tumours in mice. These studies did not however determine whether or not anti-CD25 mAbs facilitate tumour rejection by depletion of regulatory T cells or by binding to tumour-specific effector cells. Using a murine model of melanoma we have found that treatment of mice with anti-CD25 mAb facilitates long-term CD4+ T cell-mediated tumour immunity through depl...
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Bibliographic Details
- Journal:
- Cancer immunity
- Volume:
- 2
- Pages:
- 1
- Publication date:
- 2002-02-01
- EISSN:
-
1424-9634
- ISSN:
-
1424-9634
- Source identifiers:
-
26100
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:26100
- UUID:
-
uuid:b5d54b8f-08e7-458f-a407-fee6a8f9e1fc
- Local pid:
- pubs:26100
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2002
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