Journal article icon

Journal article

1,25-Dihydroxyvitamin D(3) and prostaglandin E(2) act directly on circulating human osteoclast precursors.

Abstract:

1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) and prostaglandin E(2) (PGE(2)) are known to influence osteoclast formation indirectly through their effects on osteoblasts. To determine whether 1, 25(OH)(2)D(3) and PGE(2) also have a direct effect on circulating osteoclast precursors, these factors were added to long-term cultures of human peripheral blood mononuclear cells (PBMCs) in the presence of osteoprotegerin ligand and macrophage colony-stimulating factor (M-CSF) (+/-dexamethasone). The ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1006/bbrc.1999.1545

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Biochemical and biophysical research communications More from this journal
Volume:
264
Issue:
2
Pages:
590-595
Publication date:
1999-10-01
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
Language:
English
Keywords:
Pubs id:
pubs:103817
UUID:
uuid:b5d485b0-76d5-4716-908a-8ae70389d2b7
Local pid:
pubs:103817
Source identifiers:
103817
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP