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Structure and immunogenicity of a peptide vaccine, including the complete HIV-1 gp41 2F5 epitope: implications for antibody recognition mechanism and immunogen design.

Abstract:

The membrane-proximal external region (MPER) of gp41 harbors the epitope recognized by the broadly neutralizing anti-HIV 2F5 antibody, a research focus in HIV-1 vaccine development. In this work, we analyze the structure and immunogenic properties of MPERp, a peptide vaccine that includes the following: (i) the complete sequence protected from proteolysis by the 2F5 paratope; (ii) downstream residues postulated to establish weak contacts with the CDR-H3 loop of the antibody, which are believe...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m113.527747

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Publisher:
American Society for Biochemistry and Molecular Biology Inc.
Journal:
Journal of biological chemistry More from this journal
Volume:
289
Issue:
10
Pages:
6565-6580
Publication date:
2014-03-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258

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