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Journal article

Effect of human intestinal macrophages on immunoglobulin production by human intestinal mononuclear cells isolated from patients with inflammatory bowel disease.

Abstract:

The effect of macrophages on spontaneous immunoglobulin production by isolated human intestinal mononuclear cells (MNC) is unknown. Depletion of macrophages by adherence to fibronectin or by panning with macrophage-specific monoclonal antibody 3C10 lead to a significant reduction in IgA. IgG and IgM production by intestinal MNC from both normal (n = 10) and inflammatory bowel disease (IBD) (n = 13) mucosa. The reduction in immunoglobulin produced by macrophage-depleted intestinal MNC was grea...

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Publication status:
Published

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Journal:
Clinical and experimental immunology
Volume:
79
Issue:
1
Pages:
35-40
Publication date:
1990-01-05
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:b5cd2b62-9d7d-41ab-aaab-e62a60282fb8
Source identifiers:
135428
Local pid:
pubs:135428

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