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What are the genomic drivers of the rapid evolution of PRDM9?

Abstract:

Mammalian Prdm9 has been proposed to be a key determinant of the positioning of chromosome double-strand breaks during meiosis, a contributor to speciation processes, and the most rapidly evolving gene in human, and other animal, genomes. Prdm9 genes often exhibit substantial variation in their numbers of encoded zinc fingers (ZFs), not only between closely related species but also among individuals of a species. The near-identity of these ZF sequences appears to render them very unstable in ...

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Publisher copy:
10.1016/j.tig.2011.02.001

Authors


Journal:
Trends in genetics : TIG
Volume:
27
Issue:
5
Pages:
165-171
Publication date:
2011-05-01
DOI:
ISSN:
0168-9525
Source identifiers:
239524
Language:
English
Keywords:
Pubs id:
pubs:239524
UUID:
uuid:b5cc218c-e6f7-4180-99bc-4b4956dd38f2
Local pid:
pubs:239524
Deposit date:
2012-12-19

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