- Abstract:
-
Indole-3-acetic acid (IAA) and some derivatives can be oxidised by horseradish peroxidase (HRP) to cytotoxic species. Upon treatment with IAA/HRP, liposomes undergo lipid peroxidation, strand breaks and adducts are formed in supercoiled plasmid DNA, and mammalian cells in culture lose colony-forming ability. IAA is only toxic after oxidative decarboxylation; no effects are seen when IAA or HRP is incubated independently in these systems at equivalent concentrations. Toxicity is similar in bot...
Expand abstract - Publisher copy:
- 10.1016/s0006-2952(00)00498-6
-
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- Journal:
- Biochemical pharmacology
- Volume:
- 61
- Issue:
- 2
- Pages:
- 129-136
- Publication date:
- 2001-01-05
- DOI:
- EISSN:
-
1873-2968
- ISSN:
-
0006-2952
- URN:
-
uuid:b5c901db-8c0d-4fd7-bf7f-68bbaa9ac773
- Source identifiers:
-
256279
- Local pid:
- pubs:256279
- Copyright date:
- 2001
Journal article
Oxidative activation of indole-3-acetic acids to cytotoxic species- a potential new role for plant auxins in cancer therapy.
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