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Oxidative activation of indole-3-acetic acids to cytotoxic species- a potential new role for plant auxins in cancer therapy.

Abstract:

Indole-3-acetic acid (IAA) and some derivatives can be oxidised by horseradish peroxidase (HRP) to cytotoxic species. Upon treatment with IAA/HRP, liposomes undergo lipid peroxidation, strand breaks and adducts are formed in supercoiled plasmid DNA, and mammalian cells in culture lose colony-forming ability. IAA is only toxic after oxidative decarboxylation; no effects are seen when IAA or HRP is incubated independently in these systems at equivalent concentrations. Toxicity is similar in bot...

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
Journal:
Biochemical pharmacology
Volume:
61
Issue:
2
Pages:
129-136
Publication date:
2001-01-05
DOI:
EISSN:
1873-2968
ISSN:
0006-2952
URN:
uuid:b5c901db-8c0d-4fd7-bf7f-68bbaa9ac773
Source identifiers:
256279
Local pid:
pubs:256279

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