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Journal article

Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis.

Abstract:

Proliferating cell nuclear antigen (PCNA) has been shown to interact with a variety of DNA polymerases (pol) such as pol delta, pol epsilon, pol iota, pol kappa, pol eta, and pol beta. Here we show that PCNA directly interacts with the newly discovered pol lambda cloned from human cells. This interaction stabilizes the binding of pol lambda to the primer template, thus increasing its affinity for the hydroxyl primer and its processivity in DNA synthesis. However, no effect of PCNA was detecte...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m206889200

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Journal:
Journal of biological chemistry
Volume:
277
Issue:
50
Pages:
48434-48440
Publication date:
2002-12-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
417385
Language:
English
Keywords:
Pubs id:
pubs:417385
UUID:
uuid:b5be11f8-228b-4e21-b9b0-eabd8cbfeff2
Local pid:
pubs:417385
Deposit date:
2013-11-16

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