- Abstract:
-
The clinically used beta-lactamase inhibitor clavulanic acid is produced by fermentation of Streptomyces clavuligerus. The orf6 gene of the clavulanic acid biosynthetic gene cluster in S. clavuligerus encodes a protein that shows sequence homology to ornithine acetyltransferase (OAT), the fifth enzyme of the arginine biosynthetic pathway. Orf6 was overexpressed in Escherichia coli (at approximately 15% of total soluble protein by SDS/PAGE analysis) indicating it was not toxic to the host cell...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1046/j.1432-1033.2002.02853.x
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- Journal:
- European journal of biochemistry / FEBS
- Volume:
- 269
- Issue:
- 8
- Pages:
- 2052-2059
- Publication date:
- 2002-04-05
- DOI:
- EISSN:
-
1432-1033
- ISSN:
-
0014-2956
- URN:
-
uuid:b5a7817b-6465-43fc-b7c1-3a7e68770637
- Source identifiers:
-
32099
- Local pid:
- pubs:32099
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity.
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