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Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors.

Abstract:

Regulation of survival, expansion, and differentiation of erythroid progenitors requires the well-controlled activity of signaling pathways induced by erythropoietin (Epo) and stem cell factor (SCF). In addition to qualitative regulation of signaling pathways, quantitative control may be essential to control appropriate cell numbers in peripheral blood. We demonstrate that Bruton's tyrosine kinase (Btk) is able to associate with the Epo receptor (EpoR) and Jak2, and is a substrate of Jak2. De...

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Publisher copy:
10.1084/jem.20031109

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
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Journal:
The Journal of experimental medicine
Volume:
199
Issue:
6
Pages:
785-795
Publication date:
2004-03-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:b585e4e8-da9f-49ed-9ab4-07e8718761b7
Source identifiers:
273606
Local pid:
pubs:273606

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