Journal article
Low-risk lifestyle and health factors and risk of mortality and vascular complications in Chinese patients with diabetes
- Abstract:
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Background
There is an evidence gap about whether a low-risk lifestyle is as important as achieving blood pressure (BP) and random blood glucose (RBG) control.
Objectives
To explore the long-term impacts and relative importance of low-risk lifestyle and health factors on the risk of all-cause and cancer mortality and macrovascular and microvascular complications among patients with diabetes.
Methods
This study included 26,004 diabetes patients in the China Kadoorie Biobank. We defined 5 lifestyle factors (smoking, alcohol drinking, physical activity, fruit and vegetable intake, and waist-to-hip ratio) and 2 health factors (BP and RBG). Cox regression was used to yield adjusted hazard ratios (HRs) and CIs for individual and combined lifestyle and health factors with the risks of diabetes-related outcomes.
Results
There were 5063 deaths, 6848 macrovascular complications, and 2055 microvascular complications that occurred during a median follow-up of 10.2 years. Combined low-risk lifestyle factors were associated with lower risk of all main outcomes, with HRs (95% CIs) for participants having 4 to 5 low-risk factors vs 0 to 1 of 0.50 (0.44-0.57) for all-cause mortality, 0.55 (0.43-0.71) for cancer mortality, 0.60 (0.54-0.67) for macrovascular complications, and 0.75 (0.62-0.91) for microvascular complications. The combined 4 to 5 low-risk lifestyle factors showed relative importance in predicting all-cause and cancer mortality and macrovascular complications.
Conclusions
Assuming causality exists, our findings suggest that adopting a low-risk lifestyle should be regarded as important as achieving ideal BP and glycemic goals in the prevention and management of diabetes-related adverse outcomes.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 982.9KB, Terms of use)
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- Publisher copy:
- 10.1210/clinem/dgac264
Authors
- Publisher:
- Oxford University Press
- Journal:
- The Journal of Clinical Endocrinology and Metabolism More from this journal
- Volume:
- 107
- Issue:
- 9
- Pages:
- e3919-e3928
- Publication date:
- 2022-04-23
- Acceptance date:
- 2022-04-21
- DOI:
- EISSN:
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1945-7197
- ISSN:
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0021-972X
- Pmid:
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35460564
- Language:
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English
- Keywords:
- Pubs id:
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1251681
- Local pid:
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pubs:1251681
- Deposit date:
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2022-10-12
Terms of use
- Copyright holder:
- Sun et al.
- Copyright date:
- 2022
- Rights statement:
- This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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