A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis.

Journal article

The phosphoinositide phosphatidylinositol 4, 5-bisphosphate (PtdIns(4,5)P(2)) is essential for many cellular processes and is linked to the etiology of numerous human diseases . PtdIns(4,5)P(2) has been indirectly implicated as a negative regulator of apoptosis ; however, it is unclear if apoptotic stimuli negatively regulate PtdIns(4,5)P(2) levels in vivo. Here, we show that two apoptotic-stress stimuli, hydrogen peroxide (H(2)O(2)) and UV irradiation, cause PtdIns(4,5)P(2) depletion during ...

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Authors: Halstead, JR; van Rheenen, J; Snel, M; Meeuws, S; Mohammed, S

• Publication status: Published
• Journal: Current biology : CB
• Volume: 16
• Issue: 18
• Pages: 1850-1856
• Publication date: 2006-09-01
• DOI: 10.1016/j.cub.2006.07.066
• EISSN: 1879-0445
• ISSN: 0960-9822
• Language: English
• Keywords: Phosphorylation; Phosphatidylinositol Phosphates; Mitogen-Activated Protein Kinase 3; Enzyme Activation; Humans; src-Family Kinases; Caspases; Green Fluorescent Proteins; Hela Cells; Apoptosis; Hydrogen Peroxide; Recombinant Fusion Proteins; Phosphatidylinositol 4,5-Diphosphate; Signal Transduction; Mitogen-Activated Protein Kinase 1; Ultraviolet Rays; Animals; Tyrosine; Down-Regulation; Phosphotransferases (Alcohol Group Acceptor); Mice