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The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme.

Abstract:

The structure of mouse L1210 dihydrofolate reductase (DHFR) complexed with NADPH and trimethoprim has been refined at 2.0 A resolution. The analogous complex with NADPH and methotrexate has been refined at 2.5 A resolution. These structures reveal for the first time details of drug interactions with a mammalian DHFR, which are compared with those observed from previous X-ray investigations of DHFR/inhibitor complexes. The refined L1210 structure has been used as the basis for the construction...

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Publication status:
Published

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Authors


Stammers, DK More by this author
Champness, JN More by this author
Beddell, CR More by this author
Eliopoulos, E More by this author
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Journal:
FEBS letters
Volume:
218
Issue:
1
Pages:
178-184
Publication date:
1987-06-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:b55acfb9-a49d-4914-a21d-eaba9309d917
Source identifiers:
72662
Local pid:
pubs:72662

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