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Immediate or delayed mild hypothermia prevents focal cerebral infarction.

Abstract:

The protective effect of mild hypothermia was studied in rodent models of both permanent and transient focal cerebral ischemia. In Expt. 1, Wistar rats were exposed to 6 h permanent ischemia by bilateral occlusion of both common carotid arteries and right middle cerebral artery. In Expt. 2, animals were exposed to 3 h transient ischemia followed by 21 h reperfusion, and in Expt. 3, 3 h transient ischemia was followed by 69 h of reperfusion. Expt. 4 used 3 h transient ischemia followed by 3 h ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Role:
Author
Journal:
Brain research
Volume:
587
Issue:
1
Pages:
66-72
Publication date:
1992-07-05
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
URN:
uuid:b54f3496-a0d4-4517-aecd-f81a988b3195
Source identifiers:
80169
Local pid:
pubs:80169

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