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INDEPENDENT EXPRESSION OF HLA AND BETA-2- MICROGLOBULIN ON HUMAN-MOUSE HYBRIDS

Abstract:

Direct cytotoxicity and absorption analysis were used to detect HLA antigens on man/mouse somatic cell hybrids. Confirmation of the assignment of the Major Histocompatibility Complex to chromosome 6 was obtained. The same series of hybrids were used to study the interaction between HLA and β2m on the cell surface. Results obtained from a series of clones indicated that there was complete independence of expression of HLA and β2m. Human β2m was found to be unnecessary for the normal serologica...

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Publication status:
Published

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Publisher copy:
10.1007/BF01542686

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, Molecular Medicine
Role:
Author
Publisher:
Kluwer Academic Publishers-Plenum Publishers
Journal:
SOMATIC CELL GENETICS
Volume:
2
Issue:
6
Pages:
483-496
Publication date:
1976-01-01
DOI:
EISSN:
1572-9931
ISSN:
0098-0366
URN:
uuid:b54e19b2-661c-4da7-87f9-ca69f6bf07e8
Source identifiers:
487545
Local pid:
pubs:487545
Language:
English

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