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ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells.

Abstract:

Islet cell autoantigen of 69kDa (ICA69) is a small GTPase-binding protein of unknown function. ICA69 is enriched in the Golgi complex and its N-terminal half contains a BAR domain, a module that can bind/bend membranes and interacts with phospholipids. Here we show that in insulinoma INS-1 cells ICA69 binds to the small GTPase Rab2, which regulates the transport of COPI vesicles between the endoplasmic reticulum and the Golgi complex. Rab2 binds to ICA69 in a GTP-dependent fashion and recruit...

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Publisher copy:
10.1016/j.ejcb.2007.11.003

Authors


Pietropaolo, M More by this author
Solimena, M More by this author
Journal:
European journal of cell biology
Volume:
87
Issue:
4
Pages:
197-209
Publication date:
2008-04-05
DOI:
EISSN:
1618-1298
ISSN:
0171-9335
URN:
uuid:b533cfa2-137d-4197-b88b-6db8209c8d14
Source identifiers:
310269
Local pid:
pubs:310269

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