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Cyclin A2 is required for sister chromatid segregation, but not separase control, in mouse oocyte meiosis.

Abstract:

In meiosis, two specialized cell divisions allow the separation of paired chromosomes first, then of sister chromatids. Separase removes the cohesin complex holding sister chromatids together in a stepwise manner from chromosome arms in meiosis I, then from the centromere region in meiosis II. Using mouse oocytes, our study reveals that cyclin A2 promotes entry into meiosis, as well as an additional unexpected role; namely, its requirement for separase-dependent sister chromatid separation in...

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Publication status:
Published

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Journal:
Cell reports
Volume:
2
Issue:
5
Pages:
1077-1087
Publication date:
2012-11-05
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
URN:
uuid:b53139df-cddf-4ac0-80e4-467ca1c65282
Source identifiers:
358322
Local pid:
pubs:358322

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