Cyclin A2 is required for sister chromatid segregation, but not separase control, in mouse oocyte meiosis.

Journal article

In meiosis, two specialized cell divisions allow the separation of paired chromosomes first, then of sister chromatids. Separase removes the cohesin complex holding sister chromatids together in a stepwise manner from chromosome arms in meiosis I, then from the centromere region in meiosis II. Using mouse oocytes, our study reveals that cyclin A2 promotes entry into meiosis, as well as an additional unexpected role; namely, its requirement for separase-dependent sister chromatid separation in...

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Authors: Touati, SA; Cladière, D; Lister, L; Leontiou, I; Chambon, J

• Publication status: Published
• Journal: Cell reports
• Volume: 2
• Issue: 5
• Pages: 1077-1087
• Publication date: 2012-11-01
• DOI: 10.1016/j.celrep.2012.10.002
• EISSN: 2211-1247
• ISSN: 2211-1247
• Language: English
• Keywords: Meiosis; Separase; Securin; Cells, Cultured; Cyclin A2; Chromosome Segregation; Oocytes; Chromatids; Cell Cycle Proteins; Cyclin-Dependent Kinases; Carrier Proteins; Cyclin B1; Kinetochores; Mice; Centromere; Anaphase; Animals; Endopeptidases; Metaphase