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Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells

Abstract:

Despite their inherent proximity to circulating oxygen and nutrients, endothelial cells (ECs) oxidize only a minor fraction of glucose in mitochondria, a metabolic specialization that is poorly understood. Here we show that the glycolytic enzyme pyruvate kinase M2 (PKM2) limits glucose oxidation, and maintains the growth and epigenetic state of ECs. We find that loss of PKM2 alters mitochondrial substrate utilization and impairs EC proliferation and migration in vivo. Mechanistically, we show...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-06406-8

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
ORCID:
0000-0002-4695-4569
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ORCID:
0000-0003-2433-1851
Wilhelm, K More by this author
Romão, AM More by this author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Publication date:
2018-10-09
Acceptance date:
2018-09-01
DOI:
EISSN:
2041-1723
Pubs id:
pubs:927140
URN:
uri:b52d9ffc-9fa1-43c3-89cb-64c409a81d23
UUID:
uuid:b52d9ffc-9fa1-43c3-89cb-64c409a81d23
Local pid:
pubs:927140
Language:
English

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