The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts.

Journal article

Despite efforts from a range of disciplines, our ability to predict and combat the evolution of antibiotic resistance in pathogenic bacteria is limited. This is because resistance evolution involves a complex interplay between the specific drug, bacterial genetics and both natural and treatment ecology. Incorporating details of the molecular mechanisms of drug resistance and ecology into evolutionary models has proved useful in predicting the dynamics of resistance evolution. However, putting...

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Authors: Maclean, C; Hall, A; Perron, G; Buckling, A

• Publication status: Published
• Journal: Nature reviews. Genetics
• Volume: 11
• Issue: 6
• Pages: 405-414
• Publication date: 2010-06-01
• DOI: 10.1038/nrg2778
• EISSN: 1471-0064
• ISSN: 1471-0056
• Language: English
• Keywords: Signal Transduction; Anti-Bacterial Agents; Models, Biological; Humans; Genetics, Population; Systems Integration; Animals; Evolution, Molecular; Bacterial Infections; Drug Resistance, Bacterial