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P450(BM3) (CYP102A1): connecting the dots.

Abstract:

P450(BM3) (CYP102A1), a fatty acid hydroxylase from Bacillus megaterium, has been extensively studied over a period of almost forty years. The enzyme has been redesigned to catalyse the oxidation of non-natural substrates as diverse as pharmaceuticals, terpenes and gaseous alkanes using a variety of engineering strategies. Crystal structures have provided a basis for several of the catalytic effects brought about by mutagenesis, while changes to reduction potentials, inter-domain electron tra...

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Publication status:
Published

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Publisher copy:
10.1039/c1cs15192d

Authors


Whitehouse, CJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Inorganic Chemistry
Journal:
Chemical Society reviews
Volume:
41
Issue:
3
Pages:
1218-1260
Publication date:
2012-02-05
DOI:
EISSN:
1460-4744
ISSN:
0306-0012
URN:
uuid:b5250b6e-2307-4b36-ade2-b129c43a5251
Source identifiers:
193288
Local pid:
pubs:193288

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