Homocysteine-lowering trials for prevention of heart disease and stroke.

Journal article

Dietary supplementation with B-vitamins that lower plasma total homocysteine concentrations are expected to lower the risk of cardiovascular disease. Folic acid and vitamin B (12) lower blood homocysteine concentrations by about 25-30% in populations without folic acid fortification, but by only 10-15% in populations with fortification. In observational studies, 25% lower homocysteine is associated with about 10% less coronary heart disease (CHD) and about 20% less stroke. This review examine...

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Authors: Clarke, R

• Journal: Seminars in vascular medicine
• Volume: 5
• Issue: 2
• Pages: 215-222
• Publication date: 2005-05-01
• DOI: 10.1055/s-2005-872407
• EISSN: 1529-3505
• ISSN: 1528-9648
• Language: English
• Keywords: Stroke; Treatment Outcome; Clinical Trials as Topic; Biological Markers; Hyperhomocysteinemia; Humans; Homocysteine; Vitamin B Complex; Coronary Disease