Journal article
Copper-catalyzed asymmetric conjugate addition of alkylzirconium reagents to cyclic enones to form quaternary centers.
- Abstract:
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This protocol describes the catalytic asymmetric formation of all-carbon quaternary centers--a distinctive feature of many natural products and pharmaceuticals--via conjugate addition of alkylzirconium reagents to a tertiary enone. This methodology uses alkenes as starting materials and enables the incorporation of functional groups. The alkylzirconium reagent is generated in situ by mixing the alkene with the Schwartz reagent. The alkylzirconium is added to a solution containing a copper-lig...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Bibliographic Details
- Publisher:
- Nature Publishing Group
- Journal:
- Nature protocols More from this journal
- Volume:
- 9
- Issue:
- 1
- Pages:
- 104-111
- Publication date:
- 2014-01-01
- DOI:
- EISSN:
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1750-2799
- ISSN:
-
1754-2189
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:444270
- UUID:
-
uuid:b50d03ca-be6c-4e30-87e2-dc7b776858d9
- Local pid:
-
pubs:444270
- Source identifiers:
-
444270
- Deposit date:
-
2014-01-30
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- Copyright holder:
- Nature America, Inc
- Copyright date:
- 2014
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