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Antibody-mediated detection and physical properties of oligonucleotides labelled with multiple internal and terminal 2,4-dinitrophenyl groups.

Abstract:
DNP-labelled phosphoramidites have been used to synthesis oligonucleotides with multiple DNP reporter groups. The antibody-mediated detection and the stability of duplexes formed by these labelled oligonucleotides have been studied. A DNP-labelled deoxyuridine triphosphate has also been used to enzymatically incorporate DNP-labels into DNA via the polymerase chain reaction. The use of DNP-labelled primers in the PCR has also been investigated.

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Authors


McClean, J More by this author
Davison, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Biomedical peptides, proteins and nucleic acids : structure, synthesis and biological activity
Volume:
2
Issue:
1
Pages:
7-12
Publication date:
1996
ISSN:
1353-8616
URN:
uuid:b50c2de3-b761-4758-ba0c-c700e7daad4a
Source identifiers:
400080
Local pid:
pubs:400080

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