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High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

Abstract:

BACKGROUND: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH, EC 1.1.1.141) is the key enzyme for the inactivation of prostaglandins, regulating processes such as inflammation or proliferation. The anabolic pathways of prostaglandins, especially with respect to regulation of the cyclooxygenase (COX) enzymes have been studied in detail; however, little is known about downstream events including functional interaction of prostaglandin-processing and -metabolizing enzymes. High-affinity probes fo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0013719

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Institution:
University of Oxford
Schultz, L More by this author
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Institution:
University of Oxford
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Institution:
University of Oxford
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Molecular Libraries Initiative of the NIH Roadmap for Medical Research More from this funder
Intramural Research Program of the NHGRI More from this funder
Oxford Biomedical Research Unit More from this funder
Canadian Institutes for Health Research More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
11
Pages:
e13719
Publication date:
2010
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:b505348c-73fe-418e-a221-d3c00c2d0388
Source identifiers:
94717
Local pid:
pubs:94717

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